Apr 242010

Human Plutonium Injection Experiments
The Manhattan Project plutonium and health hazards discovered in 1941 by Glenn Seaborg and others at Berkeley, supported plutonium nuclear fission, a process that atoms of Split and published lot of energy. The plutonium has become an urgent material for a variety of the atomic bomb, uranium-235, the fissile isotopes of natural uranium was used in the type bomb others.

The first significant quantities of plutonium became available by January 1944. At that time, Seaborg warned of its potential health risks and proposed studies to learn from its immediate biological behavior. He was a key issue: the more material remained in the body, the more damage it could do. Hundreds of workers would soon be exposed to plutonium and exposure standards are needed. Overexposure is not only injured workers, it could compromise the privacy and disrupt production schedules.

About 10 percent of the supply of plutonium has been allocated for animals studies in January 1944. In the summer of this year, these studies have provided sufficient information on the retention of plutonium justify removal of several employees of Los Alamos, with previous record
exposure to further work with the hardware. Los Alamos had have been several accidental exposure of humans to plutonium, and the imminent prospect of working with much larger quantities increased the desire for even more information on metabolism.

Animal studies have shown that different species excreted early known amounts of plutonium at different rates. This meant that there was no accurate way to correlate the excretion data of animals humans. Consequently, the feeling grew among the staff of medical project to administer known amounts of plutonium at the man to take excretion data accurate. However, it was not until the winter 1944, Los Alamos Health Group staff has developed methods detect concentrations of tracer at the level of plutonium in feces. In February 1945, the group led by Louis Hempelmann and supervised by Wright Langham, used the procedure Workers of accidental ingestion of plutonium.

With a proven method to detect small amounts of plutonium in feces, Los Alamos staff met March 23, 1945, with Robert Colonel Hymer Friedell Oppenheimer and the Manhattan Engineer District (MED) to discuss “medical problems of this project and their relationship with the medical research program of the Manhattan District. “In a memorandum written three days after the meeting, Louis Hempelmann said that the Manhattan Project was invited to examine “a patient hospitalized two or Rochester Chicago be chosen for the injection of 1 to 10 micrograms of material] plutonium [and that the waste will be sent to this laboratory for analysis. “The Manhattan district has also been asked to help make arrangements for this experience “a marker for the man.” These arrangements have been made, and a medical officer MED administered the injection of plutonium first man, April 10 1945 at Oak Ridge Hospital.

Experiments, Part 1

How all injections have been coordinated or even if they were coordinated is unclear. After the test of Oak Ridge, injections were given to Billings Hospital at the University of Chicago April 26, 1945, and the University of California hospital San Francisco May 14, 1945. At the end of June, Manhattan Project entrepreneurs at the University of Rochester Strong Memorial Hospital has developed a detailed plan for “fast (1 year) Completion follow-up studies of man. “These studies have been included plutonium, uranium, lead and radioactive polonium.

Over the coming months, this plan has been revised, and September 18, 1945, Wright Langham sent the latest version Colonel Stafford Warren, head of the Manhattan District Medical Division, noting that “you and the Colonel Friedell, will Of course, having the final say on whether or not the experiment will thanks in compliance with this plan. “Plutonium Rochester experimental protocol called for 10 subjects for admission to the
Strong Memorial Hospital Ward metabolism in groups of four month for two months and two for the third month.

After injection, samples of blood, urine and faeces should be Langham shipped to Los Alamos for analysis. Documents show that from October 1945 to July 1946, Rochester injected 11 patients. One patient later (designated as HP 11) died of pneumonia and other pre-existing conditions after six days Injection of 20 February. Samuel Bassett Rochester has described this experience as an “acute” that involve collection of feces, but this performance organs and other autopsy material which was sent to Los Alamos to study.

Upon notification of the HP 11, Langham said Bassett, “If you decide to make another terminal case, I suggest you use 50 micrograms [of] plutonium instead of 5. This would allow analysis of much smaller samples and do my job considerably easier. “Langham also said,” I just learned that Chicago is the scene of two experiments using 95 terminal micrograms each. I am reasonably certain that there would be no harm using larger amounts of material if you are sure that the case is one terminal. ”

Both experiments took place in Chicago’s Billings Hospital on December 27, 1945. Both patients died of preexisting disease shortly after injections of 94.91 micrograms of plutonium.

The experimental protocols exist for studies of Rochester. Langham and others who led the study also described in broad Terms how subjects were selected. In general, the choice fell on older people (13 of them were 45 years or more) limited life expectancy. (Ten of the 16 dead who were followed less than 10 years.) Four subjects did, however, live more than 20 years after the experiments.

Although several reports by other research appeared earlier, Langham and others at Los Alamos compiled the most full account of the plutonium injection experiments. They based its findings primarily on the Rochester study. Issued Los Alamos Report LA 1151 in September 1950, the distribution and The excretion of plutonium administered intravenously to humans describes the experiments, tabulated data on plutonium
metabolism, and derived an empirical formula for calculating plutonium retained from the analysis of urine. Although himself THE 1151
remained limited until 1980, information on plutonium Studies made its way into the scientific literature, shortly after injections took place.

Experiments, Part 2

During the 1970s, Patricia W. Durbin, a biophysicist at the Lawrence Radiation Laboratory, revalued plutonium Langham excretion data. One reason could improve Durbin Langham results were unexpected given the availability of long-term survivors. During her research, she learned that they had submitted lived for 20 years after being injected. Thorough detective work revealed that four other subjects were also still alive in
early 1970s. With the approval of the ACS, the Centre’s support Radiobiology for the man to Argonne National Laboratory, and cooperation of the University of Rochester Strong Memorial The hospital, three of the four survivors were reviewed in 1973. Researchers collected and promptly published new data on the long-term modes of plutonium retention and excretion. Efforts to find and study these subjects survivors ultimately triggered controversy. In the time since the work had been done, the Government has therefore adopted requiring that the subjects give
informed consent as a condition of research. Questions have been raised if the subjects of plutonium consent for the original experiments or the 1973 follow-up examinations. Monitoring investigation resulted in two reports published in ACS internal August 1974. Both concluded that only one subject may have provided any kind of consent. The remaining 17 have participated little verifiable knowledge or experience of its risks.
In addition, reports in 1973 concluded that follow-up studies have been not done with the informed consent of subjects. Three subjects were not informed that they had been injected with plutonium experimental purposes, nor why they had been invited to return to hospital.

Although CEA has not publicly release these reports, the Agency successor, the Energy Research and Development Administration, has published a fact sheet on the issue in 1976. This the program has provided details on the experiments and briefly discussed results of the survey in 1974 ACS on informed consent.

The experiments on plutonium and the public

Publications based on studies of plutonium began to appear in medical literature since 1948. In several articles during the 1950s and early 1960s, Langham said the technique to measure plutonium excreted and returned to the validation Research on the metabolism of plutonium in humans. Some information However, remained secret for a number of years after.

The public has learned about the experiences in 1976, after ERDA issued to the sheet above. Several newspapers have carried stories focusing on the lack of informed consent and to raise questions about medical ethics, but the question seemed to arouse little public concern. Ten years later, a congressional committee issued a report criticizing the plutonium injections and approximately 30 other federal radiation experiments of man. Commonly known as the report of the subcommittee Chairman Edward Markey after J. Markey (D-Mass.), this document again stimulated Limited
media attention at the time.

What the scientific literature and other information on the experiments do not the names of substances their personal stories. This approach has been pursued by Eileen Welsome the Albuquerque Tribune, which in November 1993, published a series on the experiences and issues. The
the author had driven through government reports, scientific journals, and log files to reconstruct the facts on the experiences, including names and other personal details several subjects.

At a press conference in December 1993, Energy Secretary Hazel R. O’Leary has examined the experiences related to plutonium, in conjunction
with the release of more former classified information on a variety subjects. Under a new policy of openness, it also The Department is committed to reveal the full scope and details irradiation experiments of man by the Agency and its predecessors. The history of experiments have been widely national attention and led to public demands that the federal Government to provide full disclosure on the topics.

A year after hiring the secretary, the department located, declassified and made available many documents on injections of plutonium and other radiation of man experiences. Currently under consideration by the Advisory Committee radiation experiments on human and other, this information will provide the basis for a comprehensive analysis of these ethical studies.

Crossroads Able

Crossroads Able, a 23-kiloton air-deployed nuclear weapon detonated on July 1, 1946. This bomb used, and consumed, the infamous Demon core that took the lives of two scientists in two separate criticality accidents.

Apr 122010

Human radiation experiments

Researchers in the United States has performed thousands of radiation experiments in humans to determine the effects of ionizing radiation and radioactive contamination on the human body, usually from people who were poor, sick, or powerless. Most of these tests have been carried out, funded or controlled by the U.S. Army, Atomic Energy Commission, or various other U.S. federal government.

The experiments included a wide range of studies on things like food food radioactive or mentally handicapped children conscientious objectors, insertion of radium rods into the nose of school-age children, deliberately releasing products radioactive chemicals in U.S. and Canadian cities, to measure health effects of radioactive fallout from nuclear bomb tests by injecting pregnant women and babies with radioactive chemicals, and irradiation testicles of prisoners, among others.

Ultimately, public outcry over the experiences of the Advisory Committee on the experiences of 1994 Radiation rights.

Radioactive iodine experiments

In 1953, the U.S. Atomic Energy Commission (AEC) has several studies on the health effects of radioactive iodine in the newborns and pregnant women at the University of Iowa. In one study, researchers gave pregnant women from 100 to 200 microcuries of iodine-131, to consider the women aborted embryos in an attempt to discover at what stage, and to what extent, radioiodine crosses the placental barrier. In another study, they gave 25 infants (aged less than 36 hours and weighs from 5.5 to 8.5 pounds) of iodine-131, either orally or by injection, so that they can measure the amount of iodine in their thyroid gland.

In another study, ACS, researchers at the University of Nebraska College of Medicine fed iodine-131-28 infants in good health through a stomach tube to test the concentration of iodine in the glands of infants of the thyroid.

In 1953 an operation called “green” the ACS fell radiodine-131 and xenon-133 on a surface of 500,000 hectares, which contained three small towns near the Hanford site in Washington.

In 1953, the ACS has sponsored a study to discover whether radioiodine affected differently preterm infants born at term. In the experiment, researchers at Harper Hospital in Detroit oral iodine-131-65 preterm and term that weighed 2.1 to 5.5 kg.

Cover of the final report of Project 4.1, which examined the effects of radioactive fallout on the natives of the Marshall Islands

Cover of the final report of Project 4.1, which examined the effects of radioactive fallout on the natives of the Marshall Islands

Experiments with uranium

Between 1946 and 1947, researchers at the University of Rochester injected uranium-234 and uranium-235 at doses ranging from 6.4 to 70.7 micrograms per kilogram of body weight in six study how much uranium their kidneys could tolerate before becoming damaged.

Between 1953 and 1957, Massachusetts General Hospital, Dr. William Sweet eleven patients injected with uranium as part of research funded by the Manhattan Project. In exchange for uranium-235 for his experiments, he would send the tissues of dead patients, so researchers at the Oak Ridge National Laboratory could be analyzed to analyze the potential health effects of exposure to uranium for the atomic bomb factory workers.

Experiments with plutonium

In 1945, under the Manhattan Project, three patients at Billings Hospital at the University of Chicago have been injected with plutonium.

In 1946, six employees of a Chicago metallurgical laboratory are given water contaminated with plutonium-239, so that researchers could study how plutonium is absorbed into the digestive tract.

Experiments involving other radioactive materials

Immediately after World War II, researchers at Vanderbilt University gave 829 pregnant women in Tennessee said they were “vitamin drinks” that would improve the health of their baby, but were, in fact, mixtures containing radioactive iron to determine how fast the radioisotopes entered the placenta. At least three children are known to have died of experiments, cancer and leukemia. Four babies died of cancer in women after experiences, and women have experienced rashes, bruising, anemia, hair loss / tooth, and cancer.

From 1946 to 1953, the School of Walter E. Fernald State of Massachusetts, in an experiment sponsored by the U.S. Commission of Atomic Energy and the Quaker Oats Company, 73 mentally disabled children were fed oats containing radioactive calcium and other radio-isotopes to follow ” how nutrients are digested. Children were not told they were fed radioactive chemicals and were informed by hospital staff and researchers to join a science club. ”

In the 1950s, researchers at the Medical College of Virginia conducted experiments on the burn, most of them poor and black, without their knowledge or consent, with funding from the military and in collaboration with the ACS. In the experiments, subjects were exposed to combustion, an experimental antibiotic treatment, and injections of radioactive isotopes. The amount of radioactive phosphorus-32 injected into some of these patients, 500 microcuries, was 50 times the “acceptable” dose for a healthy individual, for people with severe burns, which probably led to mortality rates increased significantly.

Atmospheric blast from Castle Bravo tests, which killed and injured numerous indigenous Marshall Islanders and U.S. Servicemen, and are still causing numerous birth defects and other health issues in the Marshall Islands

Atmospheric blast from Castle Bravo tests, which killed and injured numerous indigenous Marshall Islanders and U.S. Servicemen, and are still causing numerous birth defects and other health issues in the Marshall Islands